Anne Marie Wilkes Dugan, usually known as Annie Wilkes, is the primary antagonist in the 1990 horror film, Misery. She is a nurse and judge to her favorite author, Paul Sheldon.

In the movie she breaks romance novelist Paul Sheldon out of his trapped car during a snowstorm. She first appears to be a kind nuturing caregiver but when she learns that Paul plans to kill off her favorite charactor, Misery Chastain, she almost kills him. She then has Paul burn his new novel and tells him to write a new one. While doing so he attempts to escape seveal times. When she learns this she brutaly breaks his ankles with a sledgehammer in an act of "hobbling".