In November 1963, Loomis receives the six-year-old Michael Audrey Myers under his care. For an initial six-month-period, Loomis is charged with spending four hours each day in therapy sessions with his patient. The mute and motionless boy had murdered his seventeen-year-old sister Judith Myers on Halloween night. Loomis is determined to find out what would cause a boy his age to commit murder.

Later Dr. Loomis meets with two superior doctors in the sanitarium's forum chamber. Loomis suggests that his patient be confined in a maximum-security ward located at Litchfield, Illinois. The two doctors brush off Loomis' request declaring that Michael was merely "a catatonic" exhibiting "comatose behavior" who does not react to any of his surroundings. Loomis insists he be taken seriously because he is convinced that his patient's blank behavior is an ingenious cover for his true nature. He also feels that the level of security at Smith's Grove is insufficient. He pleads that Michael be moved immediately to a facility where any possible escape or legalized freedom is impossible. The Smith's Grove superiors decline the doctor's requests and issue an ultimatum that Loomis keep Michael as his patient or he will be looked after by someone else. Loomis knows to his core that no one else can be trusted or even safe around Michael, so he agrees to stay with him.

On the rainy night of Monday October 30, 1978, Loomis is accompanied by his friend and medical assistant Nurse Marion Chambers; they are charged with transferring Michael back to his home county for the trial. Loomis reveals to Marion that Thorazine will be used before Michael is presented to the judge.

When the pair reach the gates of the sanitarium, they discover that many patients are wandering around the grounds. Loomis goes to the main gate to telephone the hospital, but Michael appears and nearly attacks Marion while she is waiting in the car.

Myers escapes from the Illinois state hospital hijacking the car meant for his court date transfer. His plan is to return to his hometown of Haddonfield and locate his last surviving sibling.

Dr. Loomis spends the rest of his life hunting down Michael.