Karen White was a television broadcaster and investigative journalist for KDHD news in Los Angeles.

In 1981, Karen earned the attention of a serial killer known only as Eddie. Working with police as well as the KDHD production crew, Karen decided to keep in communication with Eddie in the hopes of drawing him out. Eddie arranged for Karen to meet with him at an adult book store.

Karen met Eddie inside a private booth and Eddie forced her to watch a film of a woman being raped. He wouldn't let Karen see his face, but spoke to her in low, even tones. Police officers entered the establishment and upon hearing Karen scream in terror emptied their firearms into the booth, seemingly killing Eddie in the process.

A traumatized Karen met with psychiatrist Doctor George Waggner and told her about the incident and her subsequent memory loss. Waggner invited her to visit a community he ran called the Colony.

Karen began to suspect the truth about Waggner's colony was actually a community of werewolves. Eddie Quist returned and cornered Karen, determined to give her "a piece of his mind". He then slowly began to shape-shift into a werewolf. Karen watched the transformation in horror, but interrupted it when she threw a jar of sulfuric acid at Eddie.

Karen escaped from Eddie Quist and later met up with co-worker Chris Halloran who had come to the Colony to rescue her. They were later captured by the other werewolves and taken to a barn (or ritual center as they called it) on the property. Chris helped her to escape and they succeeded in corralling most of the werewolves into the barn, locking it. Chris then set the place on fire and let it burn.

The werewolves managed to claw their way out and one of them, Bill, chased Chris' car as Karen and he tried to get away. He pounced on top of the roof and tore his way inside whereupon he bit Karen on the shoulder. Chris shot him with his shotgun and Karen saw the beast fall into the back seat where it transformed back into Bill Neill.

Returning to L.A., Karen knew that she would become a werewolf on the next full moon. With Chris' help, she decided to transform for the first time on live television. She began reading an editorial piece that she had written, then turned into a werewolf. As per their plan, Chris then shot Karen with a rifle filled with silver bullets. Karen's live broadcast was later played off as a hoax.