Frank Mannering was a surgeon who worked at Queen's Hospital in Cardiff, England during the mid 1940s. Dr. Mannering's most interesting patient was Larry Talbot.

Through the course of his relationship with Elsa, Doctor Mannering also learned of the existence of the Frankenstein Monster. He met the monster in the ruins of Frankenstein Castle, and promised that he would do everything he could to help it. This was only a half-truth however, as Elsa and Larry believed that he would use Henry Frankenstein's journals to not only help Larry, but to artificially destroy the Frankenstein Monster through science.

Mannering and the others affected repairs on the laboratory and restored most of the electronic equipment. After pouring through Frankenstein's journal, he came to realize that both the Monster and Talbot could be destroyed simply by drawing energy out of their bodies. He had them both strapped down to operating tables as he began the procedure. The monsters broke loose and began to battle it out.

Mannering and the Baroness fled the ruins and returned to the village of Vasaria. From the top of a hill, they watched as a nearby dam was destroyed, sending flood waters raging across the valley, destroying Frankenstein's castle.